go up in smoke
US /ɡoʊ ʌp ɪn smoʊk/
UK /ɡoʊ ʌp ɪn smoʊk/

1.
andare in fumo, fallire completamente
to come to nothing; to fail completely
:
•
All their hard work went up in smoke when the project was canceled.
Tutto il loro duro lavoro andò in fumo quando il progetto fu annullato.
•
His dreams of becoming a professional athlete went up in smoke after the injury.
I suoi sogni di diventare un atleta professionista andarono in fumo dopo l'infortunio.