alienation

US /ˌeɪ.li.əˈneɪ.ʃən/
UK /ˌeɪ.li.əˈneɪ.ʃən/
1.

sự xa lánh

the feeling that you have no connection with the people around you or that you are not part of a group:

:
Depressed people frequently feel a sense of alienation from those around them.