lose your shirt
US /luːz jʊər ʃɜːrt/
UK /luːz jʊər ʃɜːrt/

1.
perder la camisa, perderlo todo
to lose a lot of money, especially by gambling or a bad investment
:
•
He lost his shirt at the casino last night.
Él perdió la camisa en el casino anoche.
•
Many investors lost their shirts during the stock market crash.
Muchos inversores perdieron la camisa durante la caída del mercado de valores.