derail
US /ˌdiːˈreɪl/
UK /ˌdiːˈreɪl/

1.
descarrilar
cause (a train or tram) to leave its tracks accidentally
:
•
The heavy snow caused the train to derail.
La fuerte nevada hizo que el tren se descarrilara.
•
An investigation is underway to determine why the train derailed.
Se está investigando por qué el tren se descarriló.
2.
descarrilar, frustrar
prevent (a plan or process) from continuing as intended
:
•
His sudden resignation threatened to derail the entire project.
Su repentina renuncia amenazó con descarrilar todo el proyecto.
•
Don't let minor setbacks derail your progress.
No dejes que pequeños contratiempos descarrilen tu progreso.