depressant
US /dɪˈpres.ənt/
UK /dɪˈpres.ənt/

1.
a drug that reduces excitability and calms a person, used to treat anxiety, tension, and sleep disorders
:
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Alcohol acts as a depressant on the central nervous system.
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The doctor prescribed a mild depressant to help her sleep.
2.
a substance or factor that causes depression or a lowering of activity or spirits
:
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The bad news acted as a real depressant on everyone's mood.
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Economic uncertainty can be a major depressant on consumer spending.