manic depression
US /ˌmæn.ɪk dɪˈpreʃ.ən/
UK /ˌmæn.ɪk dɪˈpreʃ.ən/

1.
a mental illness that causes a person to experience extreme changes in mood, from periods of great excitement and energy to periods of deep sadness and despair; also known as bipolar disorder
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She was diagnosed with manic depression after years of unpredictable mood swings.
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Treatment for manic depression often involves medication and therapy.