run its course
US /rʌn ɪts kɔrs/
UK /rʌn ɪts kɔrs/

1.
自然结束, 顺其自然
to come to a natural end; to develop and finish naturally
:
•
Their relationship had simply run its course.
他们的关系只是自然而然地结束了。
•
The doctor said the illness would have to run its course.
医生说这种病必须顺其自然。