run-down
US /ˌrʌnˈdaʊn/
UK /ˌrʌnˈdaʊn/

1.
deteriorado, negligenciado
in a poor or neglected state of repair or condition
:
•
The old house was completely run-down.
A casa antiga estava completamente deteriorada.
•
The neighborhood has become quite run-down over the years.
O bairro ficou bastante deteriorado ao longo dos anos.
2.
exausto, esgotado
tired and unwell; in poor health
:
•
After working all night, he felt completely run-down.
Depois de trabalhar a noite toda, ele se sentiu completamente exausto.
•
She's been feeling a bit run-down lately and needs a break.
Ela tem se sentido um pouco exausta ultimamente e precisa de uma pausa.