incapacitating

US /ˌɪn.kəˈpæs.ə.teɪ.t̬ɪŋ/
UK /ˌɪn.kəˈpæs.ə.teɪ.t̬ɪŋ/
1.

incapacitante

making someone unable to work or do things normally, or unable to do what they intended to do:

:
Extreme shyness can be very incapacitating.