tie someone (up) in knots
US /taɪ ˈsʌm.wʌn ʌp ɪn nɑːts/
UK /taɪ ˈsʌm.wʌn ʌp ɪn nɑːts/

1.
人を混乱させる, 人をひどく心配させる
to confuse someone or make them feel very worried or anxious
:
•
The complicated instructions really tied me up in knots.
複雑な指示で本当に混乱した。
•
The thought of the exam is tying her up in knots.
試験のことを考えると彼女はひどく心配になる。