tie someone (up) in knots

US /taɪ ˈsʌm.wʌn ʌp ɪn nɑːts/
UK /taɪ ˈsʌm.wʌn ʌp ɪn nɑːts/
"tie someone (up) in knots" picture
1.

人を混乱させる, 人をひどく心配させる

to confuse someone or make them feel very worried or anxious

:
The complicated instructions really tied me up in knots.
複雑な指示で本当に混乱した
The thought of the exam is tying her up in knots.
試験のことを考えると彼女はひどく心配になる