lose your shirt
US /luːz jʊər ʃɜːrt/
UK /luːz jʊər ʃɜːrt/

1.
大金を失う, 破産する
to lose a lot of money, especially by gambling or a bad investment
:
•
He lost his shirt at the casino last night.
彼は昨夜カジノで大金を失った。
•
Many investors lost their shirts during the stock market crash.
多くの投資家が株式市場の暴落で大金を失った。