Middle East
US /ˌmɪd.əl ˈiːst/
UK /ˌmɪd.əl ˈiːst/

1.
Medio Oriente
a large region of Western Asia and North Africa, generally comprising countries from Egypt to Iran, known for its rich history, diverse cultures, and significant oil reserves
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The conflict in the Middle East has global implications.
Il conflitto in Medio Oriente ha implicazioni globali.
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Many ancient civilizations originated in the Middle East.
Molte antiche civiltà hanno avuto origine nel Medio Oriente.