lose your shirt
US /luːz jʊər ʃɜːrt/
UK /luːz jʊər ʃɜːrt/

1.
perdere la camicia, perdere tutto
to lose a lot of money, especially by gambling or a bad investment
:
•
He lost his shirt at the casino last night.
Ha perso la camicia al casinò la scorsa notte.
•
Many investors lost their shirts during the stock market crash.
Molti investitori hanno perso la camicia durante il crollo del mercato azionario.