Meaning of the word vicissitudes in English

What does vicissitudes mean in English? Explore the meaning, pronunciation, and specific usage of this word with Lingoland.

vicissitudes

US /vɪˈsɪs.ə.tuːdz/
UK /vɪˈsɪs.ɪ.tʃuːdz/

Plural Noun

a change of circumstances or fortune, typically one that is unwelcome or unpleasant

Example:
The vicissitudes of life can be challenging.
He remained optimistic despite the many vicissitudes he faced.