someone's blood is up
US /ˈsʌm.wʌnz blʌd ɪz ʌp/
UK /ˈsʌm.wʌnz blʌd ɪz ʌp/

1.
someone is very angry or excited
:
•
When he heard the news, his blood was up and he started shouting.
•
Don't say anything to him now, his blood is really up.
someone is very angry or excited