nihilism
US /ˈnaɪ.ə.lɪ.zəm/
UK /ˈnaɪ.ə.lɪ.zəm/
1.
the rejection of all religious and moral principles, often in the belief that life is meaningless.
:
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His philosophy was rooted in nihilism, questioning all established values.
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The novel explores themes of despair and nihilism.