malignancy
US /məˈlɪɡ.nən.si/
UK /məˈlɪɡ.nən.si/

1.
the state or presence of a malignant tumor; cancer.
:
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The biopsy confirmed the malignancy of the growth.
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Early detection of malignancy is crucial for successful treatment.
2.
the quality of being evil or malevolent.
:
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There was a hint of malignancy in his smile.
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The villain's actions were driven by pure malignancy.