let somebody/something loose
US /lɛt ˈsʌmˌbɑːdi ˈsʌmˌθɪŋ luːs/
UK /lɛt ˈsʌmˌbɑːdi ˈsʌmˌθɪŋ luːs/
1.
to allow a person or animal to be free, or to allow something to be used or to happen without control
:
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The zookeepers decided to let the animals loose in the larger enclosure.
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Once he gets a microphone, he just lets himself loose and talks for hours.