irritation
US /ˌɪr.əˈteɪ.ʃən/
UK /ˌɪr.əˈteɪ.ʃən/

1.
the state of feeling annoyed, impatient, or angry
:
•
He tried to hide his irritation at the delay.
•
Her constant complaining caused him great irritation.
2.
a painful or inflamed condition of a part of the body
:
•
The rash caused severe skin irritation.
•
He experienced eye irritation from the smoke.